热疗在优化肿瘤对区域治疗反应中的作用。
The role of hyperthermia in optimizing tumor response to regional therapy.
作者信息
Moyer Hunter R, Delman Keith A
机构信息
Division of Surgical Oncology, Department of Surgery, Emory University, Atlanta, Georgia, USA.
出版信息
Int J Hyperthermia. 2008 May;24(3):251-61. doi: 10.1080/02656730701772480.
PURPOSE
To discuss the role of hyperthermia in optimizing the response to regional therapy for cancer.
METHODS
A review of the current literature discussing mechanism of action, experimental models and prospective, randomized trials was performed.
RESULTS
The mechanism of action of hyperthermia in combination with radiation and cytotoxic chemotherapy at the cellular and tissue levels is described. Data supporting the benefit of hyperthermia in conjunction with both regional, infusional chemotherapy, and locoregional radiation therapy is demonstrated. Several different histologic tumor types are covered, all with prospective evidence supporting the benefit of hyperthermia.
CONCLUSIONS
Although delivery methods for hyperthermia can be complex and difficult to implement, the data support its benefit and further endeavors to include hyperthermia as a component of regional therapy should be encouraged.
目的
探讨热疗在优化癌症区域治疗反应中的作用。
方法
对当前讨论作用机制、实验模型和前瞻性随机试验的文献进行综述。
结果
描述了热疗在细胞和组织水平上与放疗及细胞毒性化疗联合应用的作用机制。展示了支持热疗联合区域灌注化疗和局部区域放疗有益的数据。涵盖了几种不同组织学类型的肿瘤，均有前瞻性证据支持热疗的益处。
结论
尽管热疗的给药方法可能复杂且难以实施，但数据支持其益处，应鼓励进一步努力将热疗纳入区域治疗的组成部分。
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