Liu Jingwen, Wang Kai, Jin Fengying, Bin Yile, Li Jiayi, Qian Xiaofei
The First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, China.
School of Microelectronics, Fudan University, Shanghai 200433, China.
Polymers (Basel). 2025 Jun 20;17(13):1725. doi: 10.3390/polym17131725.
Photothermal electrospinning (PTE) represents an innovative fusion of electrospinning (ES) technology and photothermal therapy (PTT), where photothermal agents (PTAs) are incorporated into electrospun fibers to enable localized thermal effects under near-infrared (NIR) irradiation. The high surface area and tunable architecture of electrospun fibers provide an ideal platform for efficient PTA loading, while the precise temperature control and therapeutic efficacy of PTT significantly broaden its biomedical applications, including antibacterial therapy, anticancer treatment, tissue regeneration, and drug delivery. This review mainly focuses on the emerging field of PTE. Following an overview of the basic PTE parts (ES, PTAs, and PTT), the fabrication strategies (one- and two-step methods) of photothermal electrospun fibers and their latest advancements in both antibacterial and non-antibacterial applications are summarized. Furthermore, the current challenges are deliberated at the end of this review.
光热静电纺丝（PTE）是静电纺丝（ES）技术与光热疗法（PTT）的创新性融合，其中光热剂（PTA）被掺入静电纺丝纤维中，以在近红外（NIR）照射下实现局部热效应。静电纺丝纤维的高表面积和可调节结构为高效加载PTA提供了理想平台，而PTT精确的温度控制和治疗效果显著拓宽了其生物医学应用范围，包括抗菌治疗、抗癌治疗、组织再生和药物递送。本综述主要聚焦于PTE这一新兴领域。在概述PTE的基本组成部分（ES、PTA和PTT）之后，总结了光热静电纺丝纤维的制备策略（一步法和两步法）及其在抗菌和非抗菌应用方面的最新进展。此外，本综述末尾还探讨了当前面临的挑战。
