Arretz M, Schneider H, Wienhues U, Neupert W
Institut für Physiologische Chemie, Universität München, FRG.
Biomed Biochim Acta. 1991;50(4-6):403-12.
The mitochondrial processing enzyme consists of two components, the mitochondrial processing peptidase (MPP) and processing enhancing protein (PEP). MPP and PEP act cooperatively in proteolytic processing of mitochondrial precursor proteins. Most of the mitochondrial precursors possess aminoterminal presequences (also called "targeting sequences" or "signal sequences"), that do not display a common motif and that show only limited similarities of the cleavage sites. The mitochondrial processing peptidase is a metal-dependent endoprotease, sensitive to sulfhydryl-modifying reagents and appears to belong to a new class of proteases. MPP and PEP, together with the core 1 and core 2 proteins of the respiratory complex III, form a new protein family.
线粒体加工酶由两个组分组成，即线粒体加工肽酶（MPP）和加工增强蛋白（PEP）。MPP和PEP在线粒体前体蛋白的蛋白水解加工过程中协同作用。大多数线粒体前体具有氨基末端前序列（也称为“靶向序列”或“信号序列”），这些序列没有共同的基序，并且其切割位点仅显示出有限的相似性。线粒体加工肽酶是一种金属依赖性内切蛋白酶，对巯基修饰试剂敏感，似乎属于一类新的蛋白酶。MPP和PEP与呼吸复合物III的核心1和核心2蛋白一起形成一个新的蛋白家族。
