Hampton J R
Queen's Medical Centre, University Hospital, Nottingham, UK.
Cardiovasc Drugs Ther. 1991 Dec;5(6):983-5. doi: 10.1007/BF00143524.
Meta-analysis of clinical trials does not help the clinician to treat individual patients. A general conclusion that the reduction of high blood pressure is beneficial has to be matched by specific information about the level of blood pressure that is acceptable and about the effect of particular doses of specific drugs. Results obtained from trials of "old-fashioned" antihypertensive drugs cannot confidently be extrapolated to "modern" agents. Sufficient data do not exist to encourage universal drug treatment for patients with "mild" hypertension.
临床试验的荟萃分析无助于临床医生治疗个体患者。关于高血压降低有益这一总体结论，必须辅以关于可接受血压水平以及特定药物特定剂量效果的具体信息。从“老式”抗高血压药物试验中获得的结果不能可靠地外推至“现代”药物。目前尚无足够数据支持对“轻度”高血压患者进行普遍药物治疗。
