Leligdowicz Aleksandra, Rowland-Jones Sarah
Medical Research Council Laboratories, Fajara, Atlantic Road, PO Box 273, The Gambia, West Africa.
Expert Rev Vaccines. 2008 Apr;7(3):319-31. doi: 10.1586/14760584.7.3.319.
In the past 25 years, life survival curves of many countries have been remodeled owing to HIV infection. Both HIV-1 and HIV-2 can cause AIDS, yet patients infected with HIV-2 fare much better clinically and most will never experience detrimental effects of the infection. Despite over two decades of comprehensive research into vaccine development, a prophylactic vaccine is not yet realized. An essential missing link in the innovation of a successful vaccine strategy is the description of a favorable immune response that abolishes virus replication. Lessons learned from studying the role of the immune system in the long-term nonprogression characteristic of HIV-2 infection will offer insight into how a balanced immune response can protect from the destruction of the immune system associated with chronic HIV-1 infection.
在过去25年里，许多国家的生存曲线因艾滋病毒感染而重塑。HIV-1和HIV-2均可导致艾滋病，但感染HIV-2的患者临床预后要好得多，大多数人不会出现感染的有害影响。尽管在疫苗研发方面进行了二十多年的全面研究，但预防性疫苗仍未实现。成功疫苗策略创新中一个至关重要的缺失环节是对消除病毒复制的良好免疫反应的描述。研究免疫系统在HIV-2感染长期无进展特征中的作用所获得的经验教训，将为平衡免疫反应如何预防与慢性HIV-1感染相关的免疫系统破坏提供见解。
