Piconi S, Clerici M
Prima Divisione di Malattie Infettive, Università degli Studi, Milan, Italy.
Ann Ist Super Sanita. 1997;33(2):219-23.
The acquired immunodeficiency syndrome (AIDS) is a clinically multifaceted disease induced by infection with the human immunodeficiency virus (HIV). Infection with HIV is usually followed by a period of clinical latency which is followed by development of AIDS and death. The factors that influence the evolution of HIV infection, and therefore determine the natural history of the disease in each patient are currently unknown, but the profound dysregulation of immunity characteristic of HIV infection is likely to play a pivotal role in determining the outcome of the disease. Thus, the complex interplay between two different factors, HIV itself and the immune response to the virus, is at the basis of the disease. In this brief review we will summarize the evidences indicating that HIV infection is a virus-induced and mainly immunologically mediated disease.
获得性免疫缺陷综合征（艾滋病）是一种由人类免疫缺陷病毒（HIV）感染引起的临床多方面的疾病。感染HIV后通常会有一段临床潜伏期，随后会发展为艾滋病并导致死亡。目前尚不清楚影响HIV感染演变的因素，因此也无法确定每位患者疾病的自然史，但HIV感染所特有的免疫严重失调很可能在决定疾病转归中起关键作用。因此，HIV本身和对该病毒的免疫反应这两个不同因素之间的复杂相互作用是该疾病的基础。在这篇简短的综述中，我们将总结表明HIV感染是一种病毒诱导且主要由免疫介导的疾病的证据。
