Mitomycin-induced thrombotic thrombocytopenic purpura: possible successful treatment with vincristine and cyclophosphamide.

The findings and management of a patient with the mitomycin-induced syndrome of thrombotic thrombocytopenic purpura (TTP) is reported. Hyperreactivity of the cytotoxic suppressor T-cell was found. Vincristine and cyclophosphamide reversed the hematologic and renal dysfunction after administration of antiplatelet agents and plasma infusion had failed to do so.