Poorabdollah Mihan, Mehdizadeh Ehsan, Mohammadi Foruzan, Sabeti Shahram
Department of Surgical Pathology, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Science and Health Services, Tehran, Iran.
Int J Surg Pathol. 2009 Feb;17(1):51-4. doi: 10.1177/1066896908315754. Epub 2008 Apr 7.
In this report, a case of metaplastic thymoma arising in a thymic cyst wall is discussed. The patient was a 61-year-old male whose chief complaint was sweating and chest pain. Imaging study revealed a mediastinal mass with right hemithoracic extension. He underwent surgical resection of the mass and remnants of the thymus. Histologic studies showed a primary thymic neoplasm with a biphasic histologic pattern composed of 2 distinct epithelial and stromal components arising in a thymic cyst wall. Immunohistochemically, the epithelial component was cytokeratin positive and focally reactive for EMA. Marked expression of EMA and vimentin was seen in spindle cells. Metaplastic thymoma is an extremely rare variant of primary thymic epithelial neoplasms with only a few cases reported in the literature.
在本报告中，讨论了一例发生于胸腺囊肿壁的化生性胸腺瘤病例。患者为61岁男性，主要症状为出汗和胸痛。影像学检查显示纵隔肿块并向右半胸扩展。他接受了肿块及胸腺残余组织的手术切除。组织学研究显示为原发性胸腺肿瘤，具有双相组织学模式，由起源于胸腺囊肿壁的两种不同上皮和间质成分组成。免疫组化显示，上皮成分细胞角蛋白阳性，局灶性EMA反应阳性。在梭形细胞中可见EMA和波形蛋白的明显表达。化生性胸腺瘤是原发性胸腺上皮肿瘤的一种极其罕见的变异型，文献中仅报道了少数病例。
