Lu Hong-sheng, Gan Mei-fu, Zhou Tao, Wang Shuang-zhu
Taizhou Central Hospital of Taizhou Enze Medical Group, Taizhou, China.
Int J Surg Pathol. 2011 Oct;19(5):677-80. doi: 10.1177/1066896909355458. Epub 2009 Dec 24.
Metaplastic thymoma is an extremely rare tumor. To date, only 17 cases of metaplastic thymoma have been reported. To the best of the authors' knowledge, this is the second reported case of a sarcomatoid carcinoma arising in metaplastic thymoma; the carcinoma in this case is larger than that in the previous case. A 63-year-old woman with cough and asthenia for 2 weeks was admitted to the hospital. Computed tomography (CT) revealed a giant mass on the right side of the front mediastinum medium. The mediastinal tumor was excised, and additional pathological examinations, immunohistochemical tests, and electron-microscopic tests were performed. The tumor was diagnosed as a sarcomatoid carcinoma arising in metaplastic thymoma. Here, the authors discuss the clinical pathology of the sarcomatoid carcinoma arising in metaplastic thymoma and describe the biological behaviors with respect to the pathological features.
化生性胸腺瘤是一种极其罕见的肿瘤。迄今为止，仅报道过17例化生性胸腺瘤。据作者所知，这是第二例报道的起源于化生性胸腺瘤的肉瘤样癌；该病例中的癌比前一例更大。一名63岁女性因咳嗽、乏力2周入院。计算机断层扫描（CT）显示前纵隔中部右侧有一个巨大肿块。切除纵隔肿瘤，并进行了额外的病理检查、免疫组化检测和电子显微镜检测。该肿瘤被诊断为起源于化生性胸腺瘤的肉瘤样癌。在此，作者讨论了起源于化生性胸腺瘤的肉瘤样癌的临床病理，并根据病理特征描述了其生物学行为。
