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1
Why does ARNT2 behave differently from ARNT?为什么芳香烃受体核转运蛋白2（ARNT2）的表现与芳香烃受体核转运蛋白（ARNT）不同？
Toxicol Sci. 2008 May;103(1):1-3. doi: 10.1093/toxsci/kfn032.
2
cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Arnt).一种与芳烃受体核转运蛋白（Arnt）序列高度相似的新型碱性螺旋-环-螺旋/PAS因子（Arnt2）的cDNA克隆及组织特异性表达
Mol Cell Biol. 1996 Apr;16(4):1706-13. doi: 10.1128/MCB.16.4.1706.
3
Unique and overlapping transcriptional roles of arylhydrocarbon receptor nuclear translocator (Arnt) and Arnt2 in xenobiotic and hypoxic responses.芳烃受体核转运蛋白（Arnt）和Arnt2在异生物质及低氧反应中的独特与重叠转录作用
J Biol Chem. 2006 Dec 8;281(49):37507-16. doi: 10.1074/jbc.M606910200. Epub 2006 Oct 5.
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Reciprocal regulation of the basic helix-loop-helix/Per-Arnt-Sim partner proteins, Arnt and Arnt2, during neuronal differentiation.在神经元分化过程中，碱性螺旋-环-螺旋/Per-Arnt-Sim 伴侣蛋白 Arnt 和 Arnt2 的相互调节。
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Loss of Arnt (Hif1β) in mouse epidermis triggers dermal angiogenesis, blood vessel dilation and clotting defects.在小鼠表皮中缺失 Arnt（Hif1β）会触发真皮血管生成、血管扩张和凝血缺陷。
Lab Invest. 2012 Jan;92(1):110-24. doi: 10.1038/labinvest.2011.134. Epub 2011 Sep 26.
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Analysis of Ah receptor-ARNT and Ah receptor-ARNT2 complexes in vitro and in cell culture.体外及细胞培养中芳烃受体-芳烃受体核转运蛋白和芳烃受体-芳烃受体核转运蛋白2复合物的分析
Toxicol Sci. 2008 May;103(1):191-206. doi: 10.1093/toxsci/kfm300. Epub 2007 Dec 20.
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Differential distribution of hypoxia-inducible factor 1-beta (ARNT or ARNT2) in mouse substantia nigra and ventral tegmental area.缺氧诱导因子1-β（ARNT或ARNT2）在小鼠黑质和腹侧被盖区的差异分布。
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Functional diversity of vertebrate ARNT proteins: identification of ARNT2 as the predominant form of ARNT in the marine teleost, Fundulus heteroclitus.脊椎动物芳香烃受体核转运蛋白（ARNT）的功能多样性：鉴定ARNT2为硬骨鱼海湾蟾鱼中ARNT的主要形式。
Arch Biochem Biophys. 1999 Jan 1;361(1):156-63. doi: 10.1006/abbi.1998.0992.
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Expression of Arnt and Arnt2 mRNA in developing murine tissues.芳烃受体核转运蛋白（Arnt）和芳烃受体核转运蛋白2（Arnt2）mRNA在发育中的小鼠组织中的表达。
J Histochem Cytochem. 2003 Jan;51(1):41-54. doi: 10.1177/002215540305100106.
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Human variants in the neuronal basic helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) transcription factor complex NPAS4/ARNT2 disrupt function.神经元碱性螺旋-环-螺旋/Per-Arnt-Sim（bHLH/PAS）转录因子复合物NPAS4/ARNT2中的人类变体破坏功能。
PLoS One. 2014 Jan 17;9(1):e85768. doi: 10.1371/journal.pone.0085768. eCollection 2014.

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Overexpression of ARNT2 is associated with decreased cell proliferation and better prognosis in gastric cancer.ARNT2 的过表达与胃癌细胞增殖减少和预后改善相关。
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Hypoxia, Metabolism and Immune Cell Function.缺氧、代谢与免疫细胞功能
Biomedicines. 2018 May 15;6(2):56. doi: 10.3390/biomedicines6020056.
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ARNT2 is downregulated and serves as a potential tumor suppressor gene in non-small cell lung cancer.芳烃受体核转运蛋白2（ARNT2）表达下调，并作为非小细胞肺癌中的一种潜在抑癌基因发挥作用。
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Hypoxia-inducible aryl hydrocarbon receptor nuclear translocator (ARNT) (HIF-1β): is it a rare exception?缺氧诱导的芳烃受体核转运蛋白（ARNT）（缺氧诱导因子-1β）：它是一个罕见的例外吗？
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bHLH-PAS proteins in cancer.bHLH-PAS 蛋白在癌症中的作用。
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Reciprocal regulation of the basic helix-loop-helix/Per-Arnt-Sim partner proteins, Arnt and Arnt2, during neuronal differentiation.在神经元分化过程中，碱性螺旋-环-螺旋/Per-Arnt-Sim 伴侣蛋白 Arnt 和 Arnt2 的相互调节。
Nucleic Acids Res. 2013 Jun;41(11):5626-38. doi: 10.1093/nar/gkt206. Epub 2013 Apr 17.
10
Individual variation of the genetic response to bisphenol a in human foreskin fibroblast cells derived from cryptorchidism and hypospadias patients.先天性隐睾和尿道下裂患者来源的人包皮成纤维细胞中双酚 A 遗传反应的个体差异。
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本文引用的文献

1
Analysis of Ah receptor-ARNT and Ah receptor-ARNT2 complexes in vitro and in cell culture.体外及细胞培养中芳烃受体-芳烃受体核转运蛋白和芳烃受体-芳烃受体核转运蛋白2复合物的分析
Toxicol Sci. 2008 May;103(1):191-206. doi: 10.1093/toxsci/kfm300. Epub 2007 Dec 20.
2
Constitutive regulation of CYP1B1 by the aryl hydrocarbon receptor (AhR) in pre-malignant and malignant mammary tissue.芳烃受体（AhR）对癌前和恶性乳腺组织中CYP1B1的组成性调控。
J Cell Biochem. 2008 May 15;104(2):402-17. doi: 10.1002/jcb.21630.
3
The transcription factor aryl hydrocarbon receptor nuclear translocator functions as an estrogen receptor beta-selective coactivator, and its recruitment to alternative pathways mediates antiestrogenic effects of dioxin.转录因子芳烃受体核转运蛋白作为雌激素受体β选择性共激活因子发挥作用，其被募集到替代途径介导二噁英的抗雌激素作用。
Mol Endocrinol. 2008 Feb;22(2):304-16. doi: 10.1210/me.2007-0128. Epub 2007 Nov 8.
4
Dioxin receptor is a ligand-dependent E3 ubiquitin ligase.二噁英受体是一种配体依赖性E3泛素连接酶。
Nature. 2007 Mar 29;446(7135):562-6. doi: 10.1038/nature05683.
5
Unique and overlapping transcriptional roles of arylhydrocarbon receptor nuclear translocator (Arnt) and Arnt2 in xenobiotic and hypoxic responses.芳烃受体核转运蛋白（Arnt）和Arnt2在异生物质及低氧反应中的独特与重叠转录作用
J Biol Chem. 2006 Dec 8;281(49):37507-16. doi: 10.1074/jbc.M606910200. Epub 2006 Oct 5.
6
Modulation of oestrogen receptor signalling by association with the activated dioxin receptor.通过与活化的二噁英受体结合来调节雌激素受体信号传导。
Nature. 2003 May 29;423(6939):545-50. doi: 10.1038/nature01606.
7
Conditional disruption of the aryl hydrocarbon receptor nuclear translocator (Arnt) gene leads to loss of target gene induction by the aryl hydrocarbon receptor and hypoxia-inducible factor 1alpha.芳烃受体核转运蛋白（Arnt）基因的条件性破坏导致芳烃受体和缺氧诱导因子1α对靶基因诱导作用的丧失。
Mol Endocrinol. 2000 Oct;14(10):1674-81. doi: 10.1210/mend.14.10.0533.
8
cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Arnt).一种与芳烃受体核转运蛋白（Arnt）序列高度相似的新型碱性螺旋-环-螺旋/PAS因子（Arnt2）的cDNA克隆及组织特异性表达
Mol Cell Biol. 1996 Apr;16(4):1706-13. doi: 10.1128/MCB.16.4.1706.
9
Mechanism of action of a repressor of dioxin-dependent induction of Cyp1a1 gene transcription.二噁英依赖的Cyp1a1基因转录诱导抑制因子的作用机制
Mol Cell Biol. 1992 May;12(5):2115-23. doi: 10.1128/mcb.12.5.2115-2123.1992.

Why does ARNT2 behave differently from ARNT?

作者信息

Hankinson Oliver

机构信息

Department of Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, California 90095, USA.

出版信息

Toxicol Sci. 2008 May;103(1):1-3. doi: 10.1093/toxsci/kfn032.

DOI:10.1093/toxsci/kfn032
PMID:18397918
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2938178/
Abstract
摘要