Khomenko I P, Bakhtina L Yu, Zelenina O M, Kruglov S V, Manukhina E B, Bayda L A, Malyshev I Yu
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow.
Bull Exp Biol Med. 2007 Aug;144(2):174-7. doi: 10.1007/s10517-007-0282-9.
Preadaptation of cultured HT22 mouse hippocampal neurons to oxidative stress prevented cell damage induced by severe oxidative stress. This protection manifested in a decrease in metabolic disturbances in neurons. Adaptation of neurons to oxidative stress was accompanied by accumulation of HSP32 and HSP70. HSP synthesis inhibitor quercetin abolished the protective effect of adaptation under conditions of oxidative stress. Activation of HSP70 synthesis in neurons is an important mechanism for adaptive protection of cells.
培养的HT22小鼠海马神经元对氧化应激的预适应可预防严重氧化应激诱导的细胞损伤。这种保护表现为神经元代谢紊乱的减少。神经元对氧化应激的适应伴随着HSP32和HSP70的积累。HSP合成抑制剂槲皮素消除了氧化应激条件下适应的保护作用。神经元中HSP70合成的激活是细胞适应性保护的重要机制。
