蛙皮素、荔枝碱及其类似物的N端三肽对体温和血管运动反应的影响。

Effect of N-terminal tripeptides of bombesin, litorin, and their analogue on body temperature and vasomotor responses.

作者信息

Emel'yanova T G, Sosnovskaya I V, Guzevatych L S, Gorjacheva N N, Voronina T A, Evstigneeva E B, Golubovich V P

机构信息

N. N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow.

出版信息

Bull Exp Biol Med. 2007 Aug;144(2):207-9. doi: 10.1007/s10517-007-0290-9.

DOI:10.1007/s10517-007-0290-9

PMID:18399281

Abstract

Intranasal administration of bombesin caused hypothermia in rats maintained under cold conditions. N-terminal tripeptide of bombesin exhibits intrinsic vasomotor activity, while intranasal administration of its modified analogue produced a more potent hypothermic effect than intranasal bombesin.

摘要

在寒冷条件下饲养的大鼠中，经鼻给予蛙皮素会导致体温过低。蛙皮素的N端三肽具有内在的血管舒缩活性，而经鼻给予其修饰类似物产生的体温过低效应比经鼻给予蛙皮素更强。