Babcock A M, Baker D A, Moody T W
Department of Psychology, Montana State University, Bozeman 59717.
Pharmacol Biochem Behav. 1992 Nov;43(3):957-60. doi: 10.1016/0091-3057(92)90432-f.
Bombesin infusion into the preoptic area (POA) has previously been shown to induce hypothermia in rats that are food deprived or made hypoglycemic with insulin. The present study evaluated the potency and receptor specificity of this response. Bombesin was microinfused into the POA of food-deprived rats (n = 7) and insulin-pretreated rats (n = 7) at doses of 0, 5, 12, 25, and 50 ng/0.5 microliters. Changes in core body temperature (rectal) were assessed at 1 h. Hypothermia was observed under both conditions with doses as low as 5 ng (3.1 pM) as compared to vehicle (0 ng). In a separate study, infusion of the reduced peptide bond analog (Psi13,14 Leu14)bombesin (2.5 micrograms) prior to bombesin injection (25 ng) was found to prevent the hypothermic response observed in the bombesin control condition. These data suggest that bombesin is a potent hypothermic agent that interacts with gastrin-releasing peptide receptors localized within the POA region to impact thermoregulation.
先前的研究表明，向大鼠视前区（POA）注入蛙皮素可诱导禁食或用胰岛素使其血糖降低的大鼠体温过低。本研究评估了这种反应的效力和受体特异性。将蛙皮素以0、5、12、25和50 ng/0.5微升的剂量微量注入禁食大鼠（n = 7）和胰岛素预处理大鼠（n = 7）的POA。在1小时时评估核心体温（直肠温度）的变化。与溶剂（0 ng）相比，在两种情况下，低至5 ng（3.1 pM）的剂量都观察到了体温过低。在另一项研究中，发现在注射蛙皮素（25 ng）之前注入还原肽键类似物（Psi13,14 Leu14）蛙皮素（2.5微克）可预防在蛙皮素对照条件下观察到的体温过低反应。这些数据表明，蛙皮素是一种有效的体温过低诱导剂，它与位于视前区区域内的胃泌素释放肽受体相互作用，从而影响体温调节。
