Taché Y, Pittman Q, Brown M
Brain Res. 1980 Apr 28;188(2):525-30. doi: 10.1016/0006-8993(80)90050-5.
The effect of ambient temperature (Ta) on the rectal temperature (Tre) response to intraventricular injection of bombesin has been evaluated in conscious adult male rats. At Ta = 4 degrees C, bombesin (50 ng-1 microgram) caused a marked hypothermia which was dose-dependent both in terms of the magnitude and of the duration of the response. The bombesin-induced hypothermia was reduced at Ta = 24 degrees C, whereas at Ta = 31 or 33 degrees C, the peptide (1 microgram) failed to affect Tre.AtTa = 36 degrees C, bombesin 1-10 micrograms induced an elevation in Tre. The hyperthermia observed at high Ta could be reversed to hypothermia by transferring rats to cold. The analogs [d-Trp8]bombesin or [d-Leu13]bombesin, tested under the same conditions, failed to produce significant changes in Tre. These findings demonstrate that bombesin appears to act in the brain as a poikilothermic agent by disrupting thermoregulation at temperatures below or above thermoneutrality.
在成年雄性清醒大鼠中，评估了环境温度（Ta）对脑室内注射蛙皮素后直肠温度（Tre）反应的影响。在Ta = 4℃时，蛙皮素（50 ng - 1μg）引起明显的体温过低，其反应的幅度和持续时间均呈剂量依赖性。在Ta = 24℃时，蛙皮素诱导的体温过低有所减轻，而在Ta = 31或33℃时，该肽（1μg）未能影响Tre。在Ta = 36℃时，1 - 10μg的蛙皮素引起Tre升高。在高温下观察到的体温过高可通过将大鼠转移到寒冷环境中而逆转至体温过低。在相同条件下测试的类似物[D - Trp8]蛙皮素或[D - Leu13]蛙皮素未能使Tre产生显著变化。这些发现表明，蛙皮素在大脑中似乎作为一种变温剂起作用，通过在低于或高于热中性温度时破坏体温调节来发挥作用。
