Gopalacharyulu Peddinti V, Lindfors Erno, Miettinen Jarkko, Bounsaythip Catherine K, Oresic Matej
VTT Technical Research Centre of Finland, PO Box 1500, Espoo, Finland.
Int J Data Min Bioinform. 2008;2(1):54-77. doi: 10.1504/ijdmb.2008.016756.
The emergence of systems biology necessitates development of platforms to organise and interpret plentitude of biological data. We present a system to integrate data across multiple bioinformatics databases and enable mining across various conceptual levels of biological information. The results are represented as complex networks. Context dependent mining of these networks is achieved by use of distances. Our approach is demonstrated with three applications: full metabolic network retrieval with network topology study, exploration of properties and relationships of a set of selected proteins, and combined visualisation and exploration of gene expression data with related pathways and ontologies.
系统生物学的出现使得开发用于组织和解释大量生物数据的平台成为必要。我们提出了一个系统,用于整合多个生物信息学数据库中的数据,并能够跨生物信息的各种概念层次进行挖掘。结果以复杂网络的形式呈现。通过使用距离实现对这些网络的上下文相关挖掘。我们的方法通过三个应用进行了演示:通过网络拓扑研究进行全代谢网络检索、探索一组选定蛋白质的特性和关系,以及将基因表达数据与相关途径和本体进行组合可视化和探索。