泰国近期感染艾滋病毒且未接受过抗逆转录病毒治疗的人群中的抗逆转录病毒药物耐药性。
Antiretroviral drug resistance among antiretroviral-naïve persons with recent HIV infection in Thailand.
作者信息
Apisarnthanarak A, Jirayasethpong T, Sa-nguansilp C, Thongprapai H, Kittihanukul C, Kamudamas A, Tungsathapornpong A, Mundy L M
机构信息
Department of Medicine, Division of Infectious Diseases, Thammasat University Hospital, Pratumthani, Thailand.
出版信息
HIV Med. 2008 May;9(5):322-5. doi: 10.1111/j.1468-1293.2008.00562.x.
OBJECTIVES
To evaluate the prevalence and patterns of antiretroviral (ARV) drug resistance (ARV-DR) among ARV drug-naïve, recently infected persons with HIV in the 4-year interval (2003-2006) after the inception of the National Access to ARV Programme for People who have AIDS in Thailand.
METHODS
Cross-sectional study of patients with recent HIV infection for HIV risks, ARV-DR risks and baseline ARV-DR.
RESULTS
Seven of the 305 patients (2%) had baseline ARV-DR. Via contract tracing, all seven patients with transmitted ARV-DR identified sexual partners with prior ARV treatment failure and had documented low (<75%) ARV adherence. Annual ARV-DR increased from 0 to 5.2% (P=0.06) between 2003 and 2006.
CONCLUSIONS
Report of sexual partners with potential HIV and ARV drug exposures can prompt baseline ARV-DR testing of at-risk individuals, while behavioural interventions for adherence and safer sex are refined to minimize the emergence of resistance to generic, fixed-dose combination stavudine, lamivudine and nevirapine (GPO-VIR) therapy.
目的
评估泰国国家艾滋病患者抗逆转录病毒治疗项目启动后的4年期间（2003 - 2006年），初治、近期感染艾滋病毒者中抗逆转录病毒（ARV）药物耐药性（ARV - DR）的流行情况和模式。
方法
对近期感染艾滋病毒的患者进行横断面研究，了解其感染艾滋病毒的风险、ARV - DR风险和基线ARV - DR情况。
结果
305例患者中有7例（2%）存在基线ARV - DR。通过接触者追踪，所有7例传播性ARV - DR患者均确定其性伴侣之前有抗逆转录病毒治疗失败的情况，且有记录显示其抗逆转录病毒药物依从性低（<75%）。2003年至2006年期间，年度ARV - DR从0增加到5.2%（P = 0.06）。
结论
报告有潜在艾滋病毒和抗逆转录病毒药物暴露风险的性伴侣，可促使对高危个体进行基线ARV - DR检测，同时完善关于依从性和安全性行为的行为干预措施，以尽量减少对通用型固定剂量组合司他夫定、拉米夫定和奈韦拉平（GPO - VIR）疗法产生耐药性的情况。
Zotero 插件