Tabopda Turibio Kuiate, Ngoupayo Joseph, Liu Jiawei, Mitaine-Offer Anne-Claire, Tanoli Sheraz A Khan, Khan Shamsun Nahar, Ali Muhammad Shaiq, Ngadjui Bonaventure Tchaleu, Tsamo Etienne, Lacaille-Dubois Marie-Aleth, Luu Bang
Laboratoire de Chimie Organique des Substances Naturelles, LC3-UMR 7177 CNRS, Université Louis Pasteur, Centre de Neurochimie, 5 Rue Blaise Pascal, 67084 Strasbourg, France.
Phytochemistry. 2008 May;69(8):1726-31. doi: 10.1016/j.phytochem.2008.02.018. Epub 2008 Apr 8.
Four alkaloids named piperumbellactams A-D (1-4) were isolated from branches of Piper umbellatum together with known N-hydroxyaristolam II (5), N-p-coumaroyl tyramine (6), 4-nerolidylcatechol (7), N-trans-feruloyltyramine, E-3-(3,4-dihydroxyphenyl)-N-2-[4-hydroxyphenylethyl]-2-propenamide, beta-amyrin, friedelin, apigenin 8-C-neohesperidoside, acacetin 6-C-beta-d-glucopyranoside, beta-sitosterol, its 3-O-beta-d-glucopyranoside and its 3-O-beta-d-[6'-dodecanoyl]-glucopyranoside. Glycosidase inhibition, antioxidant and antifungal activities of these compounds were evaluated. Compounds 1-3 showed moderate alpha-glucosidase enzyme inhibition with IC50 values 98.07+/-0.44, 43.80+/-0.56 and 29.64+/-0.46, respectively. In DPPH radical scavenging assay, compounds 2, 3 and 6 showed potent inhibitory activity while compounds 4, 5 and 7 showed potent antifungal activity.
从伞形胡椒的枝条中分离出四种生物碱，分别命名为胡椒伞形内酰胺A-D（1-4），同时还分离出了已知的N-羟基马兜铃内酰胺II（5）、N-对香豆酰酪胺（6）、4-橙花叔醇基儿茶酚（7）、N-反式阿魏酰酪胺、E-3-（3,4-二羟基苯基）-N-2-[4-羟基苯乙基]-2-丙烯酰胺、β-香树脂醇、木栓酮、芹菜素8-C-新橙皮糖苷、刺槐素6-C-β-D-葡萄糖苷、β-谷甾醇、其3-O-β-D-葡萄糖苷及其3-O-β-D-[6'-十二烷酰基]-葡萄糖苷。对这些化合物的糖苷酶抑制、抗氧化和抗真菌活性进行了评估。化合物1-3对α-葡萄糖苷酶表现出中等程度的抑制作用，IC50值分别为98.07±0.44、43.80±0.56和29.64±0.46。在DPPH自由基清除试验中，化合物2、3和6表现出较强的抑制活性，而化合物4、5和7表现出较强的抗真菌活性。
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