Santana-Sosa E, Barriopedro M I, López-Mojares L M, Pérez M, Lucia A
Department of Physiology, Universidad Europea de Madrid, Madrid, Spain.
Int J Sports Med. 2008 Oct;29(10):845-50. doi: 10.1055/s-2008-1038432. Epub 2008 Apr 9.
Decreased ability to perform activities of daily living (ADLs) associated with deterioration in physical capacity are key determinants of the poor quality of life and loss of independence of patients with Alzheimer's disease (AD). The purpose of this study was to determine the effects of a 12-week training program (including resistance, flexibility, joint mobility and balance/coordination exercises) for Spanish patients with AD on their i) overall functional capacity (muscle strength and flexibility, agility and balance while moving, and endurance fitness), and ii) ability to perform ADLs. Using a randomized block design, 16 patients were assigned to a training (mean [SD] age: 76 [4] yrs) or control group (73 [4] yrs) (n = 8 subjects [3 male, 5 female] per group). The results showed significant improvements after training (p < 0.05) in upper and lower body muscle strength and flexibility, agility and dynamic balance, and endurance fitness (using the Senior Fitness test), gait and balance abilities (with subsequent decrease in risk of falls) (Tinetti scale) and in the ability to perform ADLs independently (Katz and Barthel scores). No changes (p > 0.05) were found in the control group over the 12-week period. Exercise training could be included in the overall medical/nursing care protocol for patients with AD.
与身体机能衰退相关的日常生活活动（ADL）能力下降是阿尔茨海默病（AD）患者生活质量差和失去独立性的关键决定因素。本研究的目的是确定一项为期12周的训练计划（包括抗阻、柔韧性、关节活动度以及平衡/协调练习）对西班牙AD患者的影响，具体包括：i）整体功能能力（肌肉力量和柔韧性、移动时的敏捷性和平衡能力以及耐力），以及ii）进行ADL的能力。采用随机区组设计，将16名患者分为训练组（平均[标准差]年龄：76[4]岁）或对照组（73[4]岁）（每组8名受试者[3名男性，5名女性]）。结果显示，训练后（p<0.05），患者的上下肢肌肉力量和柔韧性、敏捷性和动态平衡能力、耐力（使用老年人健身测试）以及步态和平衡能力（随后跌倒风险降低）（Tinetti量表）和独立进行ADL的能力（Katz和Barthel评分）均有显著改善。在12周的时间里，对照组未发现变化（p>0.05）。运动训练可纳入AD患者的整体医疗/护理方案中。
