Górniak Marcin, Rybakowski Filip, Jaracz Jan, Rybakowski Janusz
Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
Postep Psychiatr Neurol. 2021 Sep;30(3):154-161. doi: 10.5114/ppn.2021.110779. Epub 2021 Nov 26.
Most studies show that physical activity (PA) can inhibit the progression of Alzheimer's disease (AD). This research aimed to investigate the effect of 3-month moderate PA on the general functioning and cognitive abilities of AD patients.
The study included 32 patients with mild or moderate AD who scored 11-23 points in Mini-Mental State Examination (MMSE). Half of the participants were qualified to perform the exercises; the other half constituted the control group. The recommended form of activity was Nordic walking, 30 minutes, 3 days a week, for 3 months, under the supervision of the patient's carer. General functioning and the severity of cognitive deficits were assessed using the Activities of Daily Living (ADL) scale and the Montreal Cognitive Assessment scale (MoCA) before and after the 3-month study.
No improvement was observed in the overall functioning of the patients after 3 months of regular, moderate PA. Neither were there any differences in this respect between the active and inactive groups, both in patients with mild (MMSE 19-23) and moderate (MMSE 11-18) disease severity. Men showed a deterioration in overall functioning regardless of PA. No differences in cognitive functioning were observed between the active and inactive groups, the two genders or between mild (MMSE 19-23) and moderate (MMSE 11-18) subjects.
The 3-month, moderate, Nordic walking PA did not improve the overall general functioning or cognitive performance in patients with mild or moderate AD.
大多数研究表明,体育活动(PA)可以抑制阿尔茨海默病(AD)的进展。本研究旨在调查为期3个月的适度体育活动对AD患者总体功能和认知能力的影响。
该研究纳入了32例轻度或中度AD患者,他们在简易精神状态检查表(MMSE)中的得分在11 - 23分之间。一半参与者符合进行锻炼的条件;另一半构成对照组。推荐的活动形式是北欧健走,每周3天,每次30分钟,持续3个月,由患者的护理人员监督。在为期3个月的研究前后,使用日常生活活动(ADL)量表和蒙特利尔认知评估量表(MoCA)评估总体功能和认知缺陷的严重程度。
经过3个月规律的适度体育活动后,未观察到患者的总体功能有所改善。在轻度(MMSE为19 - 23)和中度(MMSE为11 - 18)疾病严重程度的患者中,活动组和非活动组在这方面均无差异。无论是否进行体育活动,男性的总体功能都出现了恶化。在活动组和非活动组、两种性别之间,以及轻度(MMSE为19 - 23)和中度(MMSE为11 - 18)受试者之间,未观察到认知功能的差异。
为期3个月的适度北欧健走体育活动并未改善轻度或中度AD患者的总体功能或认知表现。