1 CIAFEL-Research Centre in Physical Activity, Health and Leisure, Porto, Portugal.
2 Faculty of Sport, University of Porto, Porto, Portugal.
Am J Alzheimers Dis Other Demen. 2019 Mar;34(2):95-103. doi: 10.1177/1533317518813555. Epub 2018 Dec 9.
This quasi-experimental, nonrandomized study examined the feasibility and impact of a multicomponent (MT) intervention on 7 community-dwelling individuals diagnosed with probable Alzheimer's disease (AD) at mild to moderate stage. During 6 months, patients with AD and their caregivers were submitted to a biweekly exercise program, including muscle strengthening, aerobics, balance, and postural exercises. The following tests were used: Senior Fitness Test and Incremental Treadmill Test, Disability Assessment for Dementia Scale, Alzheimer Disease Assessment Scale-Cognitive, and Quality of Life-Alzheimer's. Attendance and retention mean rates were high (86% and 78%, respectively). No adverse events occurred. Results revealed a significant beneficial effect on cardiorespiratory fitness ( P = .028), upper ( P = .018) and lower ( P = .026) body muscle strength, agility ( P = .018), and ability to perform daily activities ( P = .018). Data suggest that a biweekly MT intervention is feasible to conduct in patients with AD. Findings also suggest a potential positive effect on mitigating cognitive decline and in positively influencing quality of life.
本准实验性、非随机研究旨在检验一种多组分（MT）干预措施的可行性及其对 7 名处于轻至中度阶段的可能患有阿尔茨海默病（AD）的社区居住者的影响。在 6 个月的时间里，AD 患者及其护理人员接受了每两周一次的锻炼计划，包括肌肉强化、有氧运动、平衡和姿势练习。使用了以下测试：老年人体能测试和增量跑步机测试、痴呆残疾评估量表、阿尔茨海默病评估量表认知、以及生活质量-阿尔茨海默病量表。出勤率和保留率都很高（分别为 86%和 78%）。没有发生不良事件。结果表明，心肺功能适应性（P=0.028）、上肢（P=0.018）和下肢（P=0.026）肌肉力量、敏捷性（P=0.018）以及日常活动能力（P=0.018）都有显著的有益影响。数据表明，每两周一次的 MT 干预在 AD 患者中是可行的。研究结果还表明，这种干预措施可能有助于减轻认知能力下降，并对生活质量产生积极影响。
