CMTM3可影响雄激素受体的转录活性，并抑制LNCaP细胞中PSA的表达水平。
CMTM3 can affect the transcription activity of androgen receptor and inhibit the expression level of PSA in LNCaP cells.
作者信息
Wang Yu, Li Ting, Qiu Xiaoyan, Mo Xiaoning, Zhang Yingmei, Song Quansheng, Ma Dalong, Han Wenling
机构信息
Department of Immunology, School of Basic Medical Science, Peking University Center for Human Disease Genomics, 38 Xueyuan Road, Beijing 100083, China.
出版信息
Biochem Biophys Res Commun. 2008 Jun 20;371(1):54-8. doi: 10.1016/j.bbrc.2008.03.143. Epub 2008 Apr 8.
CMTM is a novel family of proteins linking chemokines and TM4SF. Several members of this family are highly expressed in testes and regulate androgen receptor (AR) transcription activity. One member of this family, CMTM3, has the highest expression level in testes and contains one leucine zipper and two LXXLL motifs. As assessed with the dual-luciferase reporter assay, overexpression of CMTM3 represses AR transactivation, while knocking down it can increase AR transactivation. Moreover, CMTM3 inhibits prostate-specific antigen (PSA) expression in LNCaP cells at both mRNA and protein levels with no obvious influence on AR expression. Taken together, CMTM3 may play some roles in the maturation and maintenance of the male reproduction.
CMTM是连接趋化因子和TM4SF的一个新型蛋白质家族。该家族的几个成员在睾丸中高度表达，并调节雄激素受体（AR）的转录活性。这个家族的一个成员CMTM3在睾丸中的表达水平最高，包含一个亮氨酸拉链和两个LXXLL基序。通过双荧光素酶报告基因检测评估，CMTM3的过表达抑制AR反式激活，而敲低它则可增加AR反式激活。此外，CMTM3在mRNA和蛋白质水平均抑制LNCaP细胞中前列腺特异性抗原（PSA）的表达，而对AR表达无明显影响。综上所述，CMTM3可能在雄性生殖的成熟和维持中发挥某些作用。
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