Cancer Center, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Cancer Biol Med. 2020 Aug 15;17(3):528-542. doi: 10.20892/j.issn.2095-3941.2020.0032.
The CKLF-like MARVEL transmembrane domain containing (CMTM) family of genes comprises CKLF and CMTM1-8 (previously called chemokine-like factor superfamily 1-8, CKLFSF1-8). The CMTM family proteins contain a structurally conserved MAL and related proteins for vesicle trafficking and membrane linking (MARVEL) domain. Dysregulated expression of multiple CMTM family members is a common feature in many human cancer types. CMTM proteins control critical biological processes in cancer development, including growth factor receptor activation and recycling, cell proliferation, apoptosis, metastasis, and immune evasion. Emerging and evidence indicates that the mechanisms of action of most CMTM proteins are complex and multifactorial. This review highlights new findings regarding the roles of CMTM1-8 in cancer, particularly in tumor growth, metastasis, and immune evasion. Additionally, the potential clinical value of CMTMs as novel drug targets or biomarkers is discussed.
CKLF 样 MARVEL 跨膜结构域包含（CMTM）基因家族包括 CKLF 和 CMTM1-8（以前称为趋化因子样因子超家族 1-8，CKLFSF1-8）。CMTM 家族蛋白包含一个结构上保守的 MAL 和相关蛋白，用于囊泡运输和膜连接（MARVEL）结构域。多种 CMTM 家族成员的表达失调是许多人类癌症类型的共同特征。CMTM 蛋白控制着癌症发展中的关键生物学过程，包括生长因子受体的激活和循环、细胞增殖、凋亡、转移和免疫逃逸。新出现的证据表明，大多数 CMTM 蛋白的作用机制是复杂的和多因素的。这篇综述强调了 CMTM1-8 在癌症中的新发现，特别是在肿瘤生长、转移和免疫逃逸中的作用。此外，还讨论了 CMTMs 作为新型药物靶点或生物标志物的潜在临床价值。
