Li Mengxia, Luo Fangzhou, Tian Xinyao, Yin Shengyong, Zhou Lin, Zheng Shusen
Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
School of Medicine, Zhejiang University, Hangzhou, China.
Front Oncol. 2020 Nov 13;10:595973. doi: 10.3389/fonc.2020.595973. eCollection 2020.
Chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family (CMTMs) is a new gene family, consisting of CKLF and CMTM1 to CMTM8, which plays an important role in hematopoiesis system, autoimmune diseases, male reproduction etc. Abnormal expression of CMTMs is also associated with tumor genesis, development and metastasis. In this review, we briefly describe the characteristics of CMTM family, outline its functions in multiple kinds of carcinomas, and summarize the latest research on their roles in hepatocellular carcinoma which are mainly related to the expression, prognostic effect, potential functions, and mechanism of action. The CMTM family is expected to provide new ideas and targets for HCC diagnosis and treatment.
趋化因子样因子（CKLF）样含MARVEL跨膜结构域家族（CMTMs）是一个新的基因家族，由CKLF以及CMTM1至CMTM8组成，在造血系统、自身免疫性疾病、男性生殖等方面发挥重要作用。CMTMs的异常表达也与肿瘤的发生、发展和转移有关。在本综述中，我们简要描述了CMTM家族的特征，概述了其在多种癌症中的功能，并总结了其在肝细胞癌中作用的最新研究，这些研究主要涉及表达、预后影响、潜在功能和作用机制。CMTM家族有望为肝癌的诊断和治疗提供新的思路和靶点。
