Xie Gang, Cheng Jing, Zhang Junping
Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan 030032, China.
Zhongguo Fei Ai Za Zhi. 2023 Jan 20;26(1):46-51. doi: 10.3779/j.issn.1009-3419.2023.106.01.
Chemokine-like factor-like MARVEL transmembrane domain containing member/chemokine-like factor superfamily member (CMTM/CKLFSF) including CKLF and CMTM1-CMTM8 are a new family of proteins linking chemokines and transmembrane superfamilies. CMTM not only have broad chemotactic activities, but also associate with hematopoietic system, immune system, and tumor development and metastasis closely. CMTM proteins are involved in key biological processes of cancer development, which include activation and recycling of growth factor receptors, cell proliferation and metastasis, and regulation of the tumor immune microenvironment. This is a new focus of research on the relationship between CMTM and tumors, because CMTM4/CMTM6 can be considered as a regulator for programmed cell death ligand 1 (PD-L1). This paper reviews the role of CMTM family members on cancer, especially in tumor growth, metastasis and immune escape, summarize the latest findings on the relationship between CMTM and non-small cell lung cancer, and explores the potential clinical value of CMTM as a novel drug target or biomarker. .
趋化因子样因子样 MARVEL 跨膜结构域包含成员/趋化因子样因子超家族成员（CMTM/CKLFSF），包括 CKLF 和 CMTM1 - CMTM8，是连接趋化因子和跨膜超家族的新蛋白质家族。CMTM 不仅具有广泛的趋化活性，还与造血系统、免疫系统以及肿瘤的发生和转移密切相关。CMTM 蛋白参与癌症发展的关键生物学过程，包括生长因子受体的激活和循环利用、细胞增殖和转移以及肿瘤免疫微环境的调节。这是 CMTM 与肿瘤关系研究的一个新焦点，因为 CMTM4/CMTM6 可被视为程序性细胞死亡配体 1（PD - L1）的调节剂。本文综述了 CMTM 家族成员在癌症中的作用，特别是在肿瘤生长、转移和免疫逃逸方面，总结了 CMTM 与非小细胞肺癌关系的最新研究结果，并探讨了 CMTM 作为新型药物靶点或生物标志物的潜在临床价值。
