Rektor Ivan, Goldemund David, Sheardová Katerina, Rektorová Irena, Michálková Zuzana, Dufek Michal
Movement Disorders Centre and Stroke Centre, First Department of Neurology, Masaryk University, St. Anne's Teaching Hospital, Pekarska 53, 656 91 Brno, Czech Republic.
Parkinsonism Relat Disord. 2009 Jan;15(1):24-9. doi: 10.1016/j.parkreldis.2008.02.007. Epub 2008 Apr 9.
To study the impact of brain vessel pathology on the clinical status of Parkinson's disease (PD), in 57 consecutive patients the clinical and neuropsychological data were compared with clinical MRI signs of vascular impairment and with the ultrasound brain vessel investigations. There was a significant correlation between clinical and cognitive status and intimomedial thickness, which is an indicator of large vessel impairment. Cognitive status was significantly related to the pulsatility index (an indicator of small vessel impairment). This study provides evidence that subclinical vascular pathology could influence the clinical status by contributing to motor and cognitive dysfunction in PD.
为研究脑血管病变对帕金森病（PD）临床状态的影响，对57例连续患者的临床和神经心理学数据与血管损伤的临床MRI征象及脑超声血管检查结果进行了比较。临床和认知状态与内膜中层厚度（大血管损伤的指标）之间存在显著相关性。认知状态与搏动指数（小血管损伤的指标）显著相关。本研究提供了证据，表明亚临床血管病变可能通过导致PD的运动和认知功能障碍来影响临床状态。
