Shahmahmoodi Shohreh, Mehrabi Zahra, Eshraghian Mohammad Reza, Azad Talat Mokhtari, Tabatabaie Hamideh, Yousefi Maryam, Farrokhi Kobra, Gouya Mohammad Mehdi, Esteghamati Abolreza, Moosavi Taha, Zahraie Mohsen, Rad Katayoon Samimi, Shokati Zahra, Nategh Rakhshandeh
Pathobiology Department, School of Public Health and Institute of Public Health Research, Tehran University of Medical Sciences, Tehran, Iran.
J Clin Virol. 2008 Aug;42(4):409-11. doi: 10.1016/j.jcv.2008.02.013. Epub 2008 Apr 9.
In an attempt to determine the types of non-polio enteroviruses (NPEVs) in acute flaccid paralysis (AFP) cases in Iran, we detected enterovirus 71 (EV71) in an AFP case with residual paralysis for the first time. Cell culture detected no enteroviruses, while RT-PCR and subsequent sequencing revealed that the specimen was positive for EV71. EV71 is the causative agent of a variety of diseases from hand, foot and mouth disease to severe neurological complications and is now considered as an important cause of childhood acute flaccid paralysis.
为了确定伊朗急性弛缓性麻痹（AFP）病例中非脊髓灰质炎肠道病毒（NPEV）的类型，我们首次在一名留有麻痹后遗症的AFP病例中检测到了肠道病毒71型（EV71）。细胞培养未检测到肠道病毒，而逆转录聚合酶链反应（RT-PCR）及后续测序显示该标本为EV71阳性。EV71是从手足口病到严重神经并发症等多种疾病的病原体，目前被认为是儿童急性弛缓性麻痹的一个重要病因。
