EPI Laboratory, Uganda Virus Research Institute, Entebbe, Uganda.
National Institute for Communicable Diseases, Johannesburg, South Africa.
J Med Virol. 2021 Aug;93(8):4720-4728. doi: 10.1002/jmv.26804. Epub 2021 Feb 9.
Enteroviruses (EVs) are RNA viruses that can cause many clinical syndromes including acute flaccid paralysis (AFP). Within the global polio laboratory network, EVs are categorized either as polioviruses or non-polio enteroviruses (NPEVs). Specific NPEVs have been described in polio-like residual paralytic events in AFP patients. Retrospective analysis of 112 NPEV isolates from AFP patients was performed and thirty one NPEV types were identified of which 91% were Enterovirus B and 9% were Enterovirus A species. The NPEVs were distributed across the country with most patients in the eastern region (41/89; 46.1%). The highest proportion of patients were children less than 5 years (77/89; 86.5%) and male patients were more common (54/89; 60.7%). Echovirus 11 (11/89; 12.4%) was frequently observed and phylogenetic analysis of these sequences revealed high diversity. Coxsackievirus B5 (CV-B5), CV-B6, E21, and EV-B69 were only seen in patients with residual paralysis. Analyses of the EV-A71 sequence indicated a unique genogroup.
肠道病毒（EVs）是一种 RNA 病毒，可以引起多种临床综合征，包括急性弛缓性麻痹（AFP）。在全球脊髓灰质炎实验室网络中，EVs 分为脊髓灰质炎病毒或非脊髓灰质炎肠道病毒（NPEV）。在 AFP 患者类似脊灰的残留麻痹事件中，已经描述了特定的 NPEV。对 112 例 AFP 患者的 NPEV 分离株进行了回顾性分析，鉴定出 31 种 NPEV 型，其中 91%为肠道病毒 B 型，9%为肠道病毒 A 型。这些 NPEV 分布在全国各地，大多数患者在东部地区（41/89；46.1%）。患者中比例最高的是 5 岁以下的儿童（77/89；86.5%），男性患者更为常见（54/89；60.7%）。经常观察到肠道病毒 11 型（11/89；12.4%），这些序列的系统发育分析显示出高度多样性。柯萨奇病毒 B5（CV-B5）、CV-B6、E21 和 EV-B69 仅见于残留麻痹的患者。对 EV-A71 序列的分析表明存在一个独特的基因群。
