Jalbout N, Karam A N, Karam E, Feghaly C, Khalaf H
Department of Anaesthesia, Saint George Hospital, Beirut, Lebanon.
J Med Liban. 1994;42(2):69-73.
In a randomized double-blind study, Midazolam (Dormicum) (7.5 mg) was compared with Promethazine (Phenergan) (25 mg), Droperidol (2.5 mg) and placebo as premedication for 98 pre-selected patients undergoing surgery. The anxiolytic effect of the above drugs was monitored by Beck's Anxiety Inventory. 83.3% of patients who received Midazolam had a decrease in their anxiety state compared to 55.6% for Promethazine, 12% for Droperidol and 25% for placebo. The study clearly proved that Midazolam is a better anxiolytic drug compared to Droperidol and Promethazine.
在一项随机双盲研究中，将咪达唑仑（多美康）（7.5毫克）与异丙嗪（非那根）（25毫克）、氟哌利多（2.5毫克）及安慰剂相比较，作为98例预先选定的接受手术患者的术前用药。上述药物的抗焦虑作用通过贝克焦虑量表进行监测。接受咪达唑仑的患者中83.3%的焦虑状态有所减轻，相比之下，接受异丙嗪的患者为55.6%，接受氟哌利多的患者为12%，接受安慰剂的患者为25%。该研究明确证明，与氟哌利多和异丙嗪相比，咪达唑仑是一种更好的抗焦虑药物。
