Pérez de Arcelus M, Aranguren M, Andonegui J
Servicio de Oftalmología A, Complejo Hospitalario de Navarra, Pamplona, Spain.
An Sist Sanit Navar. 2012 Jan-Apr;35(1):137-41. doi: 10.4321/s1137-66272012000100014.
We describe two cases of conjunctival-cornea intraepithelial neoplasia (CIN), treated with topical IFN alfa 2b. The traditional treatment for CIN is surgical excision usually with adjunctive cryotherapy. However, residual tumour may remain, which can lead to recurrence rates of more than 50%. 5-Fluorouracil, mitomicyn C and interferon α 2b are new pharmacological agents that have proved their efficacy in the treatment of CIN. As side effects are common, we present IFN α 2b as a single therapeutic agent as an effective and optimal treatment for presumed recurrent corneal and conjunctival intraepithelial neoplasia. It offers the benefits of topical therapy and avoids the risks of surgical or other interventions - specifically, ocular surface toxicity, cicatricial conjunctival changes, and limbal stem cell deficiency.
我们描述了两例采用局部应用干扰素α 2b治疗的结膜-角膜上皮内瘤（CIN）病例。CIN的传统治疗方法是手术切除，通常辅助冷冻疗法。然而，可能会残留肿瘤，这可能导致复发率超过50%。5-氟尿嘧啶、丝裂霉素C和干扰素α 2b是已证明对CIN治疗有效的新型药物。由于副作用常见，我们将干扰素α 2b作为单一治疗药物，作为对推测为复发性角膜和结膜上皮内瘤的有效且最佳治疗方法。它具有局部治疗的优点，避免了手术或其他干预的风险，特别是眼表毒性、瘢痕性结膜改变和角膜缘干细胞缺乏。
