Radonić Elizabeta, Henigsberg Neven, Rados Marko, Mimica Ninoslav, Folnegović-Smalc Vera
Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Zagreb, Croatia.
Coll Antropol. 2008 Jan;32 Suppl 1:139-42.
Since early neuropathological findings, temporal lobe has been related to the pathophysiology of some disorders with psychotic features. The aim of this study was to compare temporal lobe volumes and asymmetry differences in patients with schizophrenia, schizoaffective and bipolar disorders, disorders that cover the whole psychotic spectrum. Temporal lobe volumes were estimated using high resolution magnetic resonance imaging in 60 subjects, 15 subjects in each patient and one healthy volunteer (control) group. There are no statistically significant differences in temporal lobe volumes among patient and control groups. Comparison of left and right temporal lobes shows that left temporal lobes are smaller than right temporal lobes, however this difference reaches statistical significance only in groups of patients with schizoaffective and bipolar disorders. Overall temporal lobe volume may be less informative in respect to neuropathology of disorders with psychotic features than volumes of specific temporal lobe structures, in particular medial temporal lobe structures.
自早期神经病理学研究结果以来，颞叶一直与某些具有精神病性特征的疾病的病理生理学相关。本研究的目的是比较精神分裂症、分裂情感性障碍和双相情感障碍患者的颞叶体积及不对称性差异，这些疾病涵盖了整个精神病性谱系。使用高分辨率磁共振成像对60名受试者进行颞叶体积估计，其中每组患者15名，还有一个健康志愿者（对照组）。患者组和对照组之间的颞叶体积没有统计学上的显著差异。左右颞叶的比较表明，左颞叶小于右颞叶，然而这种差异仅在分裂情感性障碍和双相情感障碍患者组中具有统计学意义。总体颞叶体积对于具有精神病性特征疾病的神经病理学而言，可能不如特定颞叶结构（特别是内侧颞叶结构）的体积信息量大。
