Radonić Elizabeta, Rados Marko, Kalember Petra, Bajs-Janović Maja, Folnegović-Smalc Vera, Henigsberg Neven
University of Zagreb, Croatian Institute for Brain Research, Zagreb, Croatia.
Coll Antropol. 2011 Jan;35 Suppl 1:249-52.
The reduction of hippocampal volume was frequently reported in schizophrenia, but not in bipolar disorder This volume reduction is associated with clinical features of schizophrenia, in particular with working and verbal memory impairments. Schizoaffective disorder, as a specific disorder sharing clinical features of both schizophrenia and bipolar disorder is rarely analyzed as a separate disorder in neurobiological studies. The aim of this study was to compare hippocampal volumes in separate groups of patients with schizophrenia, schizoaffective and bipolar disorder. Hippocampal volumes were estimated using high resolution magnetic resonance imaging in 60 subjects, 15 subjects in each patient and one healthy volunteer (control) group. There were no significant differences in hippocampal volume between bipolar disorder and control group. Hippocampal volume was statistically significantly reduced in the group of patients with schizophrenia and schizoaffective disorder, compared to either bipolar disorder or control group, thus supporting the hypothesis that hippocampal volume reduction could be considered as a possible neurobiological basis for clinical aspects of schizophrenia and schizoaffective disorder associated with working and verbal memory impairment.
海马体体积缩小在精神分裂症中经常被报道，但在双相情感障碍中并非如此。这种体积缩小与精神分裂症的临床特征相关，特别是与工作记忆和言语记忆受损有关。精神分裂症伴情感障碍作为一种兼具精神分裂症和双相情感障碍临床特征的特定疾病，在神经生物学研究中很少被作为一种单独的疾病进行分析。本研究的目的是比较精神分裂症、精神分裂症伴情感障碍和双相情感障碍患者单独分组的海马体体积。使用高分辨率磁共振成像对60名受试者的海马体体积进行了估计，每组患者15名受试者以及一组健康志愿者（对照组）。双相情感障碍组和对照组之间的海马体体积没有显著差异。与双相情感障碍组或对照组相比，精神分裂症组和精神分裂症伴情感障碍组患者的海马体体积在统计学上显著减小，从而支持了海马体体积缩小可被视为与工作记忆和言语记忆受损相关的精神分裂症和精神分裂症伴情感障碍临床方面可能的神经生物学基础这一假设。
