都柏林沙门氏菌与假结核耶尔森氏菌毒力质粒之间同源性的遗传分析。
Genetic analysis of homology between the virulence plasmids of Salmonella dublin and Yersinia pseudotuberculosis.
作者信息
Krause M, Harwood J, Fierer J, Guiney D
机构信息
Department of Medicine, University of California, San Diego 92103.
出版信息
Infect Immun. 1991 May;59(5):1860-3. doi: 10.1128/iai.59.5.1860-1863.1991.
Abstract
Two segments within the virulence region of Salmonella dublin plasmid pSDL2 that were homologous to regions on Yersinia pseudotuberculosis plasmid pIB1 were located with regard to the four known genes (vsdA, vsdB, vsdC, and vsdD) of pSDL2. One segment mapped upstream of vsdA within an insertion element related to IS630 of Shigella sonnei; the second was confined to a 45-bp sequence containing an inverted repeat between vsdC and vsdD. On pIB1, both areas were located in an intergenic region upstream of yopH. These results indicate that the homology between Yersinia and Salmonella virulence plasmids is not located within structural genes.
摘要
就都柏林沙门氏菌质粒pSDL2的四个已知基因（vsdA、vsdB、vsdC和vsdD）而言，确定了pSDL2毒力区域内与假结核耶尔森氏菌质粒pIB1上区域同源的两个片段。一个片段定位于与宋内志贺氏菌IS630相关的插入元件内的vsdA上游；第二个片段局限于一个45碱基对的序列，该序列在vsdC和vsdD之间包含一个反向重复序列。在pIB1上，这两个区域都位于yopH上游的基因间区域。这些结果表明，耶尔森氏菌和沙门氏菌毒力质粒之间的同源性并不位于结构基因内。
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