火鸡疱疹病毒对雏鸡进行孵化前和孵化后免疫后细胞因子基因的表达
Expression of cytokine genes following pre- and post-hatch immunization of chickens with herpesvirus of turkeys.
作者信息
Abdul-Careem Mohamed Faizal, Hunter D Bruce, Lambourne Melissa D, Read Leah R, Parvizi Payvand, Sharif Shayan
机构信息
Department of Pathobiology, University of Guelph, Guelph, Ontario, Canada.
出版信息
Vaccine. 2008 May 2;26(19):2369-77. doi: 10.1016/j.vaccine.2008.02.069. Epub 2008 Mar 25.
Induction of immune response as characterised by expression of cytokine genes in the spleen following immunization of pre- and post-hatch chickens with herpesvirus of turkeys (HVT) vaccine was studied. The pattern of expression of IFN-gamma and IL-10 genes in pre-hatch immunized chickens was different from that observed in post-hatch HVT immunized chickens. This expression pattern of cytokine genes was associated with significantly higher HVT transcripts in pre-hatch immunized chickens than in post-hatch immunized chickens. In conclusion, HVT immunization in chickens, irrespective of the age of immunization, stimulates host response characterised by the expression of cytokine genes, such as IFN-gamma and IL-10 in the spleen. However, the age of immunization appears to influence the temporal pattern of IFN-gamma and IL-10 expression as well as replication of HVT.
研究了用土耳其疱疹病毒（HVT）疫苗对孵化前和孵化后的鸡进行免疫后，以脾脏中细胞因子基因表达为特征的免疫反应诱导情况。孵化前免疫的鸡中IFN-γ和IL-10基因的表达模式与孵化后HVT免疫的鸡中观察到的不同。细胞因子基因的这种表达模式与孵化前免疫的鸡中HVT转录本显著高于孵化后免疫的鸡有关。总之，鸡的HVT免疫，无论免疫年龄如何，都会刺激以脾脏中IFN-γ和IL-10等细胞因子基因表达为特征的宿主反应。然而，免疫年龄似乎会影响IFN-γ和IL-10表达的时间模式以及HVT的复制。
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