Jacobs Laurie G
Albert Einstein College of Medicine and Montefiore Medical Center, 111 East 210 Street, Bronx, NY 10467, USA.
Cardiol Clin. 2008 May;26(2):157-67, v. doi: 10.1016/j.ccl.2007.12.010.
Warfarin, a vitamin K antagonist, is currently the most extensively used oral anticoagulant world-wide. It is prescribed for a variety of indications and has undergone extensive clinical study. Still, despite wide usage and considerable accumulated data from clinical trials demonstrating efficacy for a variety of thrombotic and thromboembolic conditions, warfarin is underutilized because its management is complex for both patients and physicians. However, despite these limitations, warfarin can be managed with relative safety, even in an elderly population.
华法林是一种维生素K拮抗剂，目前是全球使用最广泛的口服抗凝剂。它被用于多种适应症，并且已经经历了广泛的临床研究。尽管华法林使用广泛，且临床试验积累了大量数据证明其对多种血栓形成和血栓栓塞性疾病有效，但由于其对患者和医生而言管理复杂，所以未得到充分利用。然而，尽管有这些局限性，即使在老年人群中，华法林也可以相对安全地管理。
