Jacobs Laurie G
Division of Geriatrics, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY 10467, USA.
Clin Geriatr Med. 2006 Feb;22(1):17-32, vii-viii. doi: 10.1016/j.cger.2005.09.001.
Elderly patients as a group may present more of a challenge in managing warfarin therapy because of alterations in pharmacokinetics from other medications, diet, and disease; pharmacodynamic changes; increased risk for hemorrhage; and difficulty in monitoring. The elderly, however, may derive the most benefit from warfarin therapy for certain indications, such as the prevention of stroke in atrial fibrillation or recurrent events following deep venous thrombosis. Warfarin can be managed as effectively as in other populations with careful attention to these issues.
老年患者群体在华法林治疗管理方面可能带来更多挑战，这是由于其他药物、饮食和疾病导致的药代动力学改变；药效学变化；出血风险增加；以及监测困难。然而，对于某些适应证，如预防房颤中风或深静脉血栓形成后的复发事件，老年人可能从华法林治疗中获益最多。通过仔细关注这些问题，华法林可以像在其他人群中一样得到有效管理。
