尿中胶原吡啶交联物：代谢性骨病中骨吸收的特异性标志物。

Urinary pyridinium crosslinks of collagen: specific markers of bone resorption in metabolic bone disease.

作者信息

Seibel M J, Robins S P, Bilezikian J P

机构信息

Department of Medicine, Division of Endocrinology and Metabolism, University of Heidelberg Medical School, Heidelberg, Germany.

出版信息

Trends Endocrinol Metab. 1992 Sep;3(7):263-70. doi: 10.1016/1043-2760(92)90129-o.

DOI:10.1016/1043-2760(92)90129-o

PMID:18407110

Abstract

The hydroxypyridinium compounds pyridinoline and deoxypyridinoline are specific constituents of mature skeletal collagens. They are released into the circulation and excreted in the urine. Their measurement in urine is a sensitive index of the extent of ongoing bone resorption. Currently, quantification of collagen crosslinks in urine is achieved by chromatographic techniques, but more convenient immunoassays will make these measurements more widely available in the near future. Clinical applications of hydroxypyridinium markers include numerous metabolic bone disorders such as osteoporosis, primary hyperparathyroidism, Paget's disease of bone, and metastatic bone disease. Urinary pyridinium crosslinks of collagen also show great promise as markers of therapeutic efficacy in bone disorders associated with accelerated bone resorption.

摘要

羟基吡啶鎓化合物吡啶啉和脱氧吡啶啉是成熟骨骼胶原蛋白的特定成分。它们释放到循环系统中，并随尿液排出。尿液中它们的测量是正在进行的骨吸收程度的敏感指标。目前，尿液中胶原蛋白交联物的定量是通过色谱技术实现的，但更便捷的免疫测定法将使这些测量在不久的将来更广泛地应用。羟基吡啶鎓标志物的临床应用包括多种代谢性骨病，如骨质疏松症、原发性甲状旁腺功能亢进、佩吉特骨病和转移性骨病。胶原蛋白的尿吡啶鎓交联物作为与加速骨吸收相关的骨病治疗效果标志物也显示出巨大潜力。