Jongen Cynthia, Biessels Geert Jan
Department of Neurology/Image Sciences Institute, University Medical Center Utrecht, Q0S.459, P.O. Box 85500, 3508 GA Utrecht, The Netherlands.
Eur J Pharmacol. 2008 May 6;585(1):208-18. doi: 10.1016/j.ejphar.2007.11.085. Epub 2008 Mar 4.
Brain imaging provides information on brain anatomy and function and progression of cerebral abnormalities can be monitored. This may provide insight into the aetiology of diabetes related cerebral disorders. This paper focuses on the methods for the assessment of white matter hyperintensities and brain atrophy on structural brain images, mostly magnetic resonance imaging, in diabetes. These methods range from visual rating scales to advanced semi-automated and automated image processing techniques such as volumetry and voxel-based morphometry. The findings of previous imaging studies in diabetes are discussed from a methodological perspective and recommendations for future research are given.
脑成像可提供有关脑解剖结构和功能的信息，并且可以监测脑部异常情况的进展。这可能有助于深入了解糖尿病相关脑部疾病的病因。本文重点介绍了在糖尿病患者中，基于结构脑图像（主要是磁共振成像）评估白质高信号和脑萎缩的方法。这些方法从视觉评分量表到先进的半自动和自动图像处理技术，如容积测定法和基于体素的形态测量法。本文从方法学角度讨论了先前糖尿病成像研究的结果，并给出了对未来研究的建议。
