Trabace S, Nicotra M, Cappellacci S, Morellini M, Muttinelli C, Sbracia M, Di Prima M A, Masala C
Cattedra di Genetica Medica, Universitá La Sapienza, Roma, Italy.
Am J Reprod Immunol. 1991 Dec;26(4):147-9. doi: 10.1111/j.1600-0897.1991.tb00715.x.
IgG anticardiolipin antibodies (ACL) have been shown to occur in a high proportion of women with repeated unexplained miscarriages. Forty-nine women with unexplained recurrent spontaneous abortions (RSA), previously assayed for the presence of ACL by an enzyme-linked immunoabsorbent assay, were typed for HLA-DR and DQ antigens by the classical microlymphocytotoxicity test. Twenty-five women were positive for ACL and 24 were negative. HLA-DR7 was found in 24.5% of 49 habitually aborting women vs. 28% of healthy controls; but the DR7 frequency was 40% in ACL positive patients vs. 8.3% in ACL negative patients (P = 0.011). These results show that in the Italian population an association between HLA-DR7 antigen and ACL is present in women with unexplained RSA, suggesting that HLA-DR genes might control the susceptibility to specific autoantibody production.
已证实，高比例原因不明的反复流产女性体内存在抗心磷脂IgG抗体（ACL）。通过经典的微量淋巴细胞毒性试验，对49例原因不明的复发性自然流产（RSA）女性进行HLA - DR和DQ抗原分型，这些女性此前已通过酶联免疫吸附测定法检测ACL的存在。25名女性ACL呈阳性，24名呈阴性。在49例习惯性流产女性中，24.5%发现有HLA - DR7，而健康对照组为28%；但ACL阳性患者中DR7频率为40%，ACL阴性患者中为8.3%（P = 0.011）。这些结果表明，在意大利人群中，原因不明的RSA女性体内存在HLA - DR7抗原与ACL之间的关联，提示HLA - DR基因可能控制对特定自身抗体产生的易感性。
