Tandon Ravi, Cattori Valentino, Pepin Andrea C, Riond Barbara, Meli Marina L, McDonald Mike, Doherr Marcus G, Lutz Hans, Hofmann-Lehmann Regina
Clinical Laboratory, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057 Zurich, Switzerland.
Virus Res. 2008 Jul;135(1):136-43. doi: 10.1016/j.virusres.2008.02.016. Epub 2008 Apr 14.
Recently, we demonstrated that endogenous feline leukemia virus (enFeLV) loads may vary among cats of different populations and that FeLV-infected cats have higher enFeLV loads than uninfected cats. Thus, we hypothesized that enFeLV might influence the pathogenesis and outcome of FeLV infection. No significant difference in the infection outcome (regressive versus progressive infection) was observed between groups of cats with high or low enFeLV loads following FeLV-A challenge. However, cats with high enFeLV loads showed higher viral replication (plasma viral RNA and p27 antigen levels) than cats with low enFeLV loads in the early phase of the infection. The enFeLV transcription level varied at different time points, but no clear-cut pattern was observed. In conclusion, our results demonstrated an association between enFeLV loads and FeLV replication but not outcome of infection. enFeLV should be considered as an important confounder in experimental FeLV infection or vaccination studies.
最近，我们证明内源性猫白血病病毒（enFeLV）载量在不同种群的猫之间可能存在差异，并且感染FeLV的猫比未感染的猫具有更高的enFeLV载量。因此，我们推测enFeLV可能会影响FeLV感染的发病机制和结果。在接受FeLV-A攻击后，高enFeLV载量组和低enFeLV载量组的猫在感染结果（消退性感染与进行性感染）方面未观察到显著差异。然而，在感染早期，高enFeLV载量的猫比低enFeLV载量的猫表现出更高的病毒复制水平（血浆病毒RNA和p27抗原水平）。enFeLV转录水平在不同时间点有所变化，但未观察到明确的模式。总之，我们的结果表明enFeLV载量与FeLV复制之间存在关联，但与感染结果无关。在实验性FeLV感染或疫苗接种研究中，enFeLV应被视为一个重要的混杂因素。
