Storek Jan
University of Calgary, 3330 Hospital Drive NW, HSC1869, Calgary, T2N 4N1, Canada.
Expert Opin Biol Ther. 2008 May;8(5):583-97. doi: 10.1517/14712598.8.5.583.
After hematopoietic cell transplantation (HCT), there is a prolonged period of immune deficiency.
To review the recovery of immunity after HCT, including how it is influenced by the cellular contents of the graft, and therapeutic implications.
Literature review using Medline.
RESULTS/CONCLUSION: Whereas innate immunity (e.g., epithelial barriers, phagocytes, natural killer cells) typically recovers within weeks post-transplant, the recovery of adaptive immunity takes longer, months for B cells and years for T cells. The recovery is influenced by the graft contents. For example the number of CD34 cells given with the graft affects the tempo of neutrophil recovery, and the number of CD4 T cells given with the graft affects CD4 T cell counts post-transplant. Improved understanding of the relationship between graft contents and immune reconstitution could lead to graft engineering improving transplant outcomes.
造血细胞移植（HCT）后，会有一段较长时间的免疫缺陷期。
综述HCT后免疫功能的恢复情况，包括其如何受移植物细胞成分的影响以及治疗意义。
使用Medline进行文献综述。
结果/结论：虽然固有免疫（如上皮屏障、吞噬细胞、自然杀伤细胞）通常在移植后数周内恢复，但适应性免疫的恢复需要更长时间，B细胞需要数月，T细胞需要数年。恢复情况受移植物成分影响。例如，移植时给予的CD34细胞数量会影响中性粒细胞恢复的速度，移植时给予的CD4 T细胞数量会影响移植后CD4 T细胞计数。对移植物成分与免疫重建之间关系的进一步了解可能会促使移植物工程改善移植结果。
