Storek Jan, Geddes Michelle, Khan Faisal, Huard Bertrand, Helg Claudine, Chalandon Yves, Passweg Jakob, Roosnek Eddy
Division of Hematology and Hematologic Malignancies, Department of Medicine, University of Calgary, Calgary, AB, Canada.
Semin Immunopathol. 2008 Dec;30(4):425-37. doi: 10.1007/s00281-008-0132-5. Epub 2008 Oct 24.
Hematopoietic stem cell transplantation is associated with a severe immune deficiency. As a result, the patient is at high risk of infections. Innate immunity, including epithelial barriers, monocytes, granulocytes, and NK cells recovers within weeks after transplantation. By contrast, adaptive immunity recovers much slower. B- and T-cell counts normalize during the first months after transplantation, but in particular, T-cell immunity may remain impaired for years. During the last decade, much of the underlying mechanisms have been identified. These insights may provide new therapies to accelerate recovery.
造血干细胞移植与严重的免疫缺陷相关。因此，患者面临着较高的感染风险。包括上皮屏障、单核细胞、粒细胞和自然杀伤细胞在内的固有免疫在移植后数周内恢复。相比之下，适应性免疫恢复得要慢得多。B细胞和T细胞计数在移植后的头几个月内恢复正常，但特别是T细胞免疫可能会持续受损数年。在过去十年中，许多潜在机制已被确定。这些见解可能会为加速恢复提供新的治疗方法。
