Yildirim Yesim, Akcay Yesim, Ozyilkan Ozgur, Celasun Bulent
Department of Medical Oncology, Baskent University, Ankara, Turkey.
Med Princ Pract. 2008;17(3):250-2. doi: 10.1159/000117801. Epub 2008 Apr 10.
To report a rare case of small cell carcinoma of the prostate with unusual skin metastasis.
A 60-year-old was evaluated for difficulty in urinating. Abdominal computed tomography scans revealed a prostatic mass invading the surrounding tissues and multiple perirectal, periprostatic, para-aortic and pericaval lymph nodes. Needle biopsy specimens showed both small cell carcinoma and adenocarcinoma. He was treated with combination chemotherapy: cisplatin and etoposide and bilateral orchiectomy. After six cycles of the chemotherapy, disease progressed and the patient did not respond to salvage therapy; hence, palliative care was instituted. During the follow-up, papillary lesions were observed in the scrotal skin; biopsy showed metastatic small cell carcinoma.
Small cell carcinoma of the prostate is an aggressive disease with a highly metastatic potential; but skin metastases are very uncommon. It has poor prognosis despite therapy. Management resembles that of small cell carcinoma of the lung.
