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[应用单克隆抗体对甲型和乙型急性肝炎淋巴细胞亚群的研究]

[Study of lymphocyte subpopulations with monoclonal antibodies in acute hepatitis A and B].

作者信息

Collazo L, Sotto A, Morales M G, Borbolla E

机构信息

Instituto de Gastroenterología La Habana, Cuba.

出版信息

Rev Gastroenterol Peru. 1991;11(3):161-3.

PMID:1840845
Abstract

Using monoclonal antibodies, it was determined the T3, T4 and T8 1ym phocyte populations in the blood samples of 40 patients with acute viral hepatitis (20 type A and 20 type B). al patients showed complete remission from it. The results of this study were compared with those of a control group of 20 healthy subjects. There was a non significant decreased of the total number of lymphocytes measured with the T3 monoclonal antibody in both types of hepatitis. The number of T8 lymphocytes was significantly increased (p less than 0.05) when the results were compared with those of the control group. The quotient T4/T8 was diminished in the initial phase of the disease (p less than 0.05). There were no other differences between hepatitis A and hepatitis B. In the follow up of the disease, the results tend to normal values in the whole group of patients.

摘要

利用单克隆抗体,测定了40例急性病毒性肝炎患者(20例甲型和20例乙型)血样中的T3、T4和T8淋巴细胞群。所有患者均完全康复。本研究结果与20名健康受试者的对照组结果进行了比较。两种类型的肝炎中,用T3单克隆抗体测得的淋巴细胞总数均有非显著性下降。与对照组结果相比,T8淋巴细胞数量显著增加(p<0.05)。疾病初期T4/T8比值降低(p<0.05)。甲型肝炎和乙型肝炎之间没有其他差异。在疾病随访中,整个患者组的结果趋于正常。

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