Collazo L, Sotto A, Morales M G, Borbolla E
Rev Gastroenterol Mex. 1989 Oct-Dec;54(4):219-22.
We studied T3, T4 and T8 lymphocyte populations in peripheral blood by monoclonal antibodies in 40 patients with acute viral hepatitis (Type A 20; Type B 20) who underwent outcome to complete recovery. We compared the results with 20 healthy subjects (control group). We found a decrease in total lymphocytes measured by T3 monoclonal antibodies and a significant increase in T8 lymphocyte populations compared with control groups. In the early stage the T4/T8 ratio was decreased. Lymphocyte populations and T4/T8 ratio was normal in 3-6 month follow-up for the acute A hepatitis group and 3.6 month to a year follow-up for the B hepatitis group. Results were related to the humoral and clinical outcome.
我们采用单克隆抗体对外周血中的T3、T4和T8淋巴细胞群体进行了研究，研究对象为40例急性病毒性肝炎患者（甲型20例；乙型20例），这些患者最终均完全康复。我们将结果与20名健康受试者（对照组）进行了比较。我们发现，与对照组相比，用T3单克隆抗体检测的总淋巴细胞数量减少，T8淋巴细胞群体显著增加。在疾病早期，T4/T8比值降低。甲型急性肝炎组在3 - 6个月的随访中以及乙型肝炎组在3.6个月至1年的随访中，淋巴细胞群体和T4/T8比值均恢复正常。结果与体液免疫和临床转归相关。
