Damman Jeffrey, Schuurs Theo A, Ploeg Rutger J, Seelen Marc A
Department of Surgery, University Medical Center Groningen, Groningen, The Netherlands.
Transplantation. 2008 Apr 15;85(7):923-7. doi: 10.1097/TP.0b013e3181683cf5.
Long-term kidney graft survival is affected by different variables including donor condition, ischemia-reperfusion injury, and graft rejection during the transplantation process. The complement system is an important mediator of renal ischemia-reperfusion injury and in rejecting allografts. However, donor complement C3 seems to be crucial in renal transplantation-related injury as renal injury is attenuated in C3 deficient kidney grafts. Interestingly, before ischemia-reperfusion induced C3 expression, C3 is already induced in donors suffering from brain death. Therefore, strategies targeting complement activation in the brain-dead donor may increase graft viability and transplant outcome.
长期肾移植存活受多种因素影响，包括供体状况、缺血再灌注损伤以及移植过程中的移植物排斥反应。补体系统是肾缺血再灌注损伤和同种异体移植物排斥反应的重要介质。然而，供体补体C3似乎在肾移植相关损伤中起关键作用，因为在C3缺陷的肾移植中肾损伤会减轻。有趣的是，在缺血再灌注诱导C3表达之前，脑死亡供体中C3就已经被诱导表达。因此，针对脑死亡供体补体激活的策略可能会提高移植物的存活率和移植效果。
