酵母人工染色体克隆在构建基因组图谱中的作用。
The role of yeast artificial chromosome clones in generating genome maps.
作者信息
Burke D T
机构信息
Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, New Jersey 08544.
出版信息
Curr Opin Genet Dev. 1991 Jun;1(1):69-74. doi: 10.1016/0959-437x(91)80044-m.
PMID:1840880
Abstract
The cloning of large DNAs as yeast artificial chromosomes (YACs) holds the promise of greatly expanding the scope of physical genomic mapping. Recent improvements in YAC clone libraries and their screening, as well as in the analysis of YAC-cloned DNA, are beginning to fulfill the potential of this system.
摘要
将大型DNA克隆为酵母人工染色体（YAC）有望极大地扩展物理基因组图谱绘制的范围。YAC克隆文库及其筛选方法以及对YAC克隆DNA的分析方面最近取得的进展，正开始实现该系统的潜力。
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