Chae Junghyun
Department of Chemistry and Institute of Basic Sciences, Sungshin Women's University, 249-1, Dongseon-dong 3-ga, Seongbuk-gu, Seoul 136-742, Korea.
Arch Pharm Res. 2008 Mar;31(3):305-9. doi: 10.1007/s12272-001-1156-y. Epub 2008 Apr 13.
A highly practical method for demethylation of aryl methyl ethers employing a long-chain thiol has been developed. Under the conditions described herein, clean and fast conversions to the desired phenolic compounds have been achieved with a broad range of substrates. Unlike other thiolate-mediated methods, this newly developed protocol features in-situ generation of sodium alkylthiolate using NaOH, and is almost free from foul smells and potentially harmful gases. It therefore provides an attractive option for the demethylation of aryl methyl ethers.
已开发出一种使用长链硫醇对芳基甲基醚进行脱甲基的高度实用方法。在本文所述条件下，多种底物都能实现向所需酚类化合物的清洁、快速转化。与其他硫醇盐介导的方法不同，这种新开发的方案采用氢氧化钠原位生成烷基硫醇钠，几乎没有难闻气味和潜在有害气体。因此，它为芳基甲基醚的脱甲基提供了一个有吸引力的选择。
