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[4-(2-羟基苯基)噻唑-2-基]甲酮的合成作为水杨醛酰腙类生物等排体。

Synthesis of [4-(2-hydroxyphenyl)thiazol-2-yl]methanones as potential bioisosteres of salicylidene acylhydrazides.

机构信息

Department of Chemistry, Umeå University, Umeå, Sweden.

出版信息

Molecules. 2010 Aug 31;15(9):6019-34. doi: 10.3390/molecules15096019.

DOI:10.3390/molecules15096019
PMID:20877207
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6257736/
Abstract

A focused library of [4-(2-hydroxyphenyl)thiazol-2-yl]methanones was prepared in a four-step synthesis with the aim to obtain potent inhibitors of type III secretion in Gram-negative bacteria. The compounds are potential bioisosteres of salicylidene acylhydrazides that are a known class of type III secretion inhibitors.

摘要

我们通过四步合成法制备了一个[4-(2-羟基苯基)噻唑-2-基]甲酮的聚焦文库，旨在获得革兰氏阴性菌中 III 型分泌系统的有效抑制剂。这些化合物是水杨醛酰腙的潜在生物等排体，而水杨醛酰腙是已知的 III 型分泌系统抑制剂的一类。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c7/6257736/b9c42dbb4ba2/molecules-15-06019-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c7/6257736/35aeebc1dd0e/molecules-15-06019-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c7/6257736/b9c42dbb4ba2/molecules-15-06019-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c7/6257736/35aeebc1dd0e/molecules-15-06019-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c7/6257736/b9c42dbb4ba2/molecules-15-06019-g002.jpg

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