Nemoto Akinobu, Sakata Katsumi
Department of Medical Informatics, Yokohama City University Hospital.
Nihon Rinsho. 2008 Apr;66(4):789-99.
Since its introduction in the late 1980s, intrathecal baclofen(ITB) therapy has become the standard treatment for severe generalized spasticity of both spinal and cerebral origin. More than 50,000 pumps were implanted in the world. Long term efficacy of ITB therapy is excellent, although it is frequently associated with complications such as infections, catheter malfunctions, and cerebrospinal fluid leaks. There are some reports of death with withdrawal, overdose and infection. For a good results we need to discuss factors involved in selecting the appropriate treatment modalities for the individual. The treatment of these patients is optimized in the setting of a multidisciplinary team.
自20世纪80年代末引入以来，鞘内注射巴氯芬（ITB）疗法已成为治疗脊髓和脑源性严重全身性痉挛的标准疗法。全球已植入超过5万台泵。ITB疗法的长期疗效极佳，尽管它经常伴有感染、导管故障和脑脊液漏等并发症。有一些关于撤药、过量用药和感染导致死亡的报告。为了取得良好效果，我们需要讨论为个体选择合适治疗方式时涉及的因素。这些患者的治疗在多学科团队的环境中得到优化。
