Filon F Larese, Marzioti G, Fortina A Belloni, Peserico A, De Toni A, Corradini M T, Carrabba E, Fiorito A
UCO Medicina del Lavoro, Università di Trieste, Via della Pietà 19, Trieste.
G Ital Med Lav Ergon. 2007 Jul-Sep;29(3 Suppl):849-50.
Contact dermatitis is more frequent among women for anatomical reasons and for extraprofessional exposure to irritants and detergents during homeworks. In addition sensitisation to contact haptens is different in sexes. The aim of our work was to evaluate the association between patch test skin sensitizations and professional exposure to metals analyzing data for gender. Of the 15.217 patients patch tested for dermatitis, 678 were metalworkers. The statistical analysis revealed a significant association between dermatitis and sensitisation to nickel in professional exposed women (OR = 1.68; LC50% 1.11-6.50) while metal sensitisation (Cr.Ni and Co) was not relevant in men: for them a significant association between dermatitis and sensitisation was found to quaternium (OR = 3.91; LC95% 1.18-12.9), to mercaptobenzothiazole (OR = 2.69; LC50% 1.11-6.50) and to ethylendiamine dichloride (OR = 2.53; LC95% 1-6.41). The authors stress the need to evaluate patch test sensitisation considering gender effects.
由于解剖学原因以及在家务劳动中额外接触刺激物和洗涤剂，接触性皮炎在女性中更为常见。此外，两性对接触性半抗原的致敏情况也有所不同。我们这项工作的目的是通过分析性别数据来评估斑贴试验皮肤致敏与职业性金属接触之间的关联。在15217名因皮炎接受斑贴试验的患者中，有678名是金属工人。统计分析显示，职业暴露女性中皮炎与镍致敏之间存在显著关联（比值比=1.68；半数致死浓度50%为1.11 - 6.50），而男性中金属致敏（铬、镍和钴）则不相关：对他们而言，发现皮炎与季铵盐（比值比=3.91；95%可信区间下限1.18 - 12.9）、巯基苯并噻唑（比值比=2.69；半数致死浓度50%为1.11 - 6.50）和乙二胺二氯化物（比值比=2.53；95%可信区间下限1 - 6.41）致敏之间存在显著关联。作者强调在评估斑贴试验致敏时需要考虑性别影响。
